The Indianapolis Colts (2-4) will take on the rested San Francisco 49ers (2-3) on the road in the featured Sunday night game in Week 7. kickoff is 8:20 p.m. ET at Levi’s Stadium. The Colts, after losing their first three games of the season, have won two of their last three, and the one loss was in overtime against the Baltimore Ravens. They have scored at least 25 points in three straight games. QB Carson Wentz is heating up after dealing injuries to both ankles. He now has nine touchdown passes and only one interception this season, and RB Jonathan Taylor is averaging 5.4 yards per carry for 472 yards and four scores through six games.

The 49ers won their first two games of the season, only to drop their next three. They are coming off their bye week and get QB Jimmy Garoppolo back in the starting lineup after Trey Lance made his first NFL start in Week 5 in a 17-10 loss to the Arizona Cardinals. The 49ers are just a different team with Garoppolo in the lineup. They are 24-10 in the regular season when he starts, and the one time he was healthy for a full season, he took them to the Super Bowl. Their defensive front will give Wentz problems. Plus, coming off the bye, the 49ers have had extra time to prep and are playing at home, although they are 0-2 there this season.